In training: running for time is better than running for miles.
I was told running is not about the distance, but time on your feet. Plus, running for time takes pressure off younger runners from training too hard on recover/easy days. Additionally, it is easy for teams with a variety of runners with different ability levels to negotiate their training.
Example.
Runner A: 4:10 miler
Runner B: 4:25 miler
Understandably, these runners will run different distances in 50 minutes based off of recovery pace. Since runner A has a faster recover pace in comparison to runner B.
I don't know about mitochondrial levels. Although i don't think the body reacts to how far you ran, instead how long (time) you ran.
With all this being said... I still count miles. go figure.