"GW1516 was discontinued in 2007, after it was linked to the rapid development of cancer during trials on mice."

In 2007, research was published showing that high doses of GW501516 given to mice dramatically improved their physical performance; the work was widely discussed in popular media, and led to a black market for the drug candidate and to its abuse by athletes as a doping agent. The World Anti-Doping Agency (WADA) developed a test for GW501516 and other related chemicals and added them to the prohibited list in 2009; it has issued additional warnings to athletes that GW501516 is not safe.

But if we are to believe Young Issam Gatorade was mixing up huge batches of this stuff and putting it in their recovery gummies...

Athletes are easily influenced.

Athletes are ageing / in debt / near the end of a contract, and need to cash out quickly. The more pressure the athlete feels, the more erratic their decision making becomes.

Athletes have a live fast and die young attitude. Better to burn out than fade away.

etc.

I've read this as well; however, this is a popular drug amongst those who use PEDs, most not for competition and I still haven't seen any human cancer cases attributed to the drug. Apparently the dosing used on the rats was equivalent to an astronomical dose for a human.

Not saying anyone should use it, and it is a banned PED, but the cancer thing, seems to be rare or non-existent at the effective dose level.

What is the effective dose level? Is it not possible once an athlete realize the benefits of this carcinogenic, that they would increase the dosage to gain even more benefits?

It’s a favorite among Africans.

GW1516 was supposed to be "excercise in a pill" & solve the obesity problem. 😆

I think it's nandrolonoe that's #1 on their menu. 🤔

You also glow forever on this drug. G

GW1516 is detectable in the urine up to 40 days after a single oral dose of 15 mg! 😲

pubmed.ncbi.nlm.nih.gov

Detection of PPARδ agonists GW1516 and GW0742 and their metabolites in human urine - PubMed

Peroxisome proliferator-activated receptor-δ (PPARδ) agonists are the drug candidates with potential performance-enhancing properties, and therefore their illegitimate use in sports should be controlled. To simulate the metab...

Link:pubmed.ncbi.nlm.nih.gov/22977012/

If you read bodybuilding forums or other types of places that discuss SARMs and RCs and PEDs like this, you always see people say this same thing. I think it's reductionist and kind of dangerous TBQH.

This is the logic that's frequently employed:
- We likely know that taking a super large dose will give you super cancer, super fast, that's what some research in the 90s told us
- We have people taking much smaller doses and we're not hearing reports of all of them keeling over from cancer so it's probably safe

But I think there's a few other things to consider:
- It didn't really start getting used by athletes until the mid 2000s
- It didn't start hitting the gym bro population until much later, maybe 2010s?
- People who take cardarine are likely to take other substances that lack serious research
- When people get cancer, it's not always easy to pinpoint the exact thing that caused it. See my point above. Someone, maybe many, or maybe zero people, could have gotten cancer from cardarine but we might have no way of knowing exactly what caused it.

This is correct. Even Rekrunner says that, although he is always very skeptical and logical and analytical. So it's 100% proven. Big corporations don't mind secretly synthesizing and selling illegal drugs!

Yes, I think the decision to use PEDs is not as clear cut and as easy as we all like to think it is. If you took the same decision outside of athletics, and put it in other professional situations, would be as judgmental?

If you were an attorney, or surgeon, or whatever.. and you KNEW that if you took an injection once a week that would allow you to maximize your abilities, to earn more, to accomplish more, to secure money and the security that comes with it for your family would you do it?

Now, imagine if NOT taking it not only meant you would excel, it means you have to totally change your profession. The stakes are even higher and consequences more far reaching.

I agree with this line of thinking. Do I care that Mick Jagger at 80 is dancing, prancing and running up and down the stage at a RS concert? Surely he must take some HGH or PEDs of some kind to keep going (although I do not know for sure or care).

Similarly, I would actually endorse the US president taking similar 'supplements', if it helped him run the country better or helped him keep his thoughts coherent. And that would go for any candidate as well. There are so many pharmaceutics out there that help us with cholesterol, blood pressure, etc., etc., etc. There is a drug for practically every organ in the body and for so many diseases! A PED to make you a better surgeon is a good thing.

Seems we have this notion that competitive athletes should perform their events, clean. Which I agree.

how would you even know that? someone gets cancer- they get cancer. there's no marker that said this or that person got it from some specific etiology. some mma guy gets pancreatic cancer, and they're more than likely not going to come out and say, "oh well, i think i was done in by my GW 501." why in the world would you seemingly downplay the massive deleterious effects of this substance?

This, 100%

For a male distance runner or cyclist, you only reallly “need” 3 drugs - EPO, HGH, and testosterone. Yes, in massive doses they can be dangerous, but they’re some of the safest drugs on the market as there all naturally made by your body.

It’s not like you’re experimenting with research chemicals and barely studied compounds

Don't want to help anyone dope, so not going to answer your first question.

As for your second, certainly and that is one of the reasons you see so many deaths in bodybuilding, why there where so many deaths in cycling from EPO in the 90s - pushing the dosages to extreme levels in an attempt to obtain the largest possible competitive advantages.

Valid points and should be considered by anyone who chooses to take the substance.

Rats and mice live less than 3 years, so they develop cancer very quickly. This drug hasn't been around long enough to even estimate cancer risks in humans which could take decades. The people taking drugs like this that never even made it to human clinical trials are absolutely insane.