Drug InteractionsConcomitant use of tizanidine with fluvoxamine or ciprofloxacin is contraindicated due to significant hypotension and increased psychomotor impairment.[25][26]Because of potential drug interactions, using tizanidine with other CYP1A2 inhibitors such as oral contraceptives containing Ethinyl estradiol and gestodene, dronedarone, pimozide, saquinavir, cimetidine, famotidine, acyclovir, and ticlopidine should be avoided due to decreased clearance of tizanidine.[27]Adverse reactions such as hypotension, bradycardia, or excessive sedation require dose reduction or stopping therapy gradually.Tizanidine should be used cautiously in patients on other alpha-2 adrenergic receptor agonists.Patients should avoid alcohol and benzodiazepines with tizanidine as it can lead to excessive sedation and myocardial toxicity in rare instances.[28]
I am a retired neurologist and have prescribed tizanidine as an anti-spasticity medication for patients with MS, ALS and spinal cord injury. Any athlete taking this without a prescription for a legitimate medical reason is playing a dangerous game. Please don't take it.