Now That's Telling It Like It Is wrote:
LoneStarXC wrote:
A five-second google search and I found this:
https://www.ncbi.nlm.nih.gov/m/pubmed/24263659/
Wow...amazing study! Double blinded and everything. So, Salazar is trying to pull out all the tricks to improve performance with his athletes? I've heard somewhere that Salazar sent an email to Armstrong about IV L-carnitine and how excited how he would be at this, or something along those lines? Imagine - Lance excited about a performance enhancing substance...who would have thought. ?
L-carnitine works in some studies and does not work in other studies.
L-carnitine research goes back a long time.
Here is a study with marathon runners (instead of soccer players) from the year 1996, which showed no effect:
https://www.ncbi.nlm.nih.gov/m/pubmed/24263659/A double-blind crossover field study was performed to investigate the effects of acute L-carnitine supplementation on metabolism and performance of endurance-trained athletes during and after a marathon run. Seven male subjects were given supplements of 2 g L-carnitine 2 h before the start of a marathon run and again after 20 km of the run. The plasma concentration of metabolites and hormones was analysed 1 h before, immediately after and 1 h after the run, as well as the next morning after the run. In addition, the respiratory exchange ratio (R) was determined before and at the end of the run, and a submaximal performance test was completed on a treadmill the morning after the run. The administration of L-carnitine was associated with a significant increase in the plasma concentration of all analysed carnitine fractions (i.e. free carnitine, short-chain acylcarnitine, long-chain acylcarnitine, total acid soluble carnitine, total carnitine) but caused no significant change in marathon running time, in R, in the plasma concentrations of carbohydrate metabolites (glucose, lactate, pyruvate), of fat metabolites (free fatty acids, glycerol, beta-hydroxybutyrate), of hormones (insulin, glucagon, cortisol), and of enzyme activities (creatine kinase, lactate dehydrogenase). Moreover, there was no difference in the result of the submaximal performance test the morning after the run.
In conclusion:
1) Acute oral administration of 4 grams of L-carnitine did not affect the metabolism or improve the physical performance of the endurance-trained athletes during the run and did not alter their recovery.
Coach Alberto and Dr. Jeffrey Brown used an intravenous dose of L-carnitine which turned out to be... a little bit higher than the oral dose of 4 grams used in this study.
For example:
There were 4 x 100 mL L-carnitine IV bags prepared at the pharmacy for Dr. Jeffrey Brown the day before the infusion.
The worksheet showed that they were prepared with a concentration of 9.67 grams of L-carnitine/45 mL of saline = 0.2149 grams per mL = 214.9 mg/mL.
An IV infusion of just 1 of the 100 mL bags would be a total dose of 21.49 grams (= 21,490 mg) of L-carnitine. They administered 1 to 4 bags total.
A 100 mL IV of any concentration of L-carnitine without a TUE is an anti-doping rule violation (ADRV).
A typical IV dose of L-carnitine is 50 mg/kg. = 3,000 mg (= 3 grams) for a 60 kg. person.
L-carnitine can be given by a slow IV injection over 2 to 3 minutes. The total dose of 3,000 mg is only a 15 mL injection of L-carnitine at 200 mg/mL.
There is no need for an IV L-carnitine infusion of over an hour duration.
Did they inform the 5 NOP athletes of any possible risks or side effects of the L-carnitine infusions?
Did they inform the 5 NOP athletes that the L-carnitine infusions were over the 50 mL limit... without a TUE...which would make the infusion an ADRV?
It is recommended that a plasma carnitine concentration be obtained prior to beginning this parenteral therapy. Weekly and monthly monitoring is recommended as well. This monitoring should include blood chemistries, vital signs, plasma carnitine concentrations (the plasma free carnitine concentration should be between 35 and 60 micromol/L) and overall clinical condition.
Some of the NOP athletes had extremely high plasma carnitine concentrations of over 2,000 micromol/L after the IV L-carnitine infusions administered by Dr. Brown for COACH Alberto Salazar...which were about 40X normal levels.
Coach Alberto and Dr. Brown administered the 100 mL bags. They administered 1 to 4 bags. They did not administer 15 mL ( = 3,000 mg of L-carnitine) because that dose does not raise plasma carnitine concentrations from 35-60 micromol/L to 2000 micromol/L after the IV infusion of L-carnitine.
The IV infusion had a duration of over 1 hour.
Even though L-carnitine is available in the US as pills or powder for oral use, L-carnitine for intravenous injection or infusion is a prescription drug.
The idea for the L-carnitine infusions came from Alberto Salazar and not from Dr. Brown. Dr. Brown just does what Alberto tells him to do and he is paid by someone (Nike?) to see all the NOP athletes.
Coach Alberto has played doctor and practiced medicine without a license on many occasions.
He has dispensed the prescription NSAID drug Celebrex to athletes without a prescription for Celebrex, which is illegal because Alberto is not a doctor or a pharmacy.
He has had Mo Farah, Dathan Ritzenhein and other runners on the prescription drug calcitonin... until Pete Julian found out that it might increase cancer risk.
Whoops.
The athletes were then told to stop taking calcitonin...after Dathan Ritzenhein had already been taking it for 4 years.
Alberto Salazar dispensed the schedule III controlled substance and prescription drug Androgel (testosterone gel) to his 2 experimental subjects (his 2 sons) when he did the "Possible Galen Rupp Sabotage with Androgel Experiments" with measurement of testosterone/epitestosterone (T/E) levels to see what amount would trigger a positive doping test. That is against various federal and state drug laws because Alberto is not a doctor or pharmacy and neither of his 2 sons had a prescription for Androgel. It is illegal to dispense a schedule III controlled substance and prescription drug Androgel to any person who does not have a prescription for Androgel.
Alberto Salazar has also emailed Galen Rupp and told Galen to increase his dose of the prescription thyroid hormone drug Levoxyl (T4) and to start on the prescription drug Cytomel (T3) right away. He then offers to drive the prescription thyroid hormone drug Cytomel over to Galen.
Alberto Salazar is coach, doctor and pharmacy all in one.
In a Dec. 20, 2011 email to Galen Rupp from Coach Alberto Salazar:
"Take a full extra Levoxyl tonight and start on Cytomel right away.
"P.S. I've got Cytomel. If you don't have it, call me and I'll drive it over."
Coach Alberto Salazar should not be "playing doctor" with Galen Rupp by telling him to increase his dose of Levoxyl and to start on Cytomel at the same time, which could cause side effects.
Coach Alberto Salazar should also not act like a pharmacy delivery service for Galen Rupp.
http://www.spiegel.de/international/world/is-nike-covering-up-dubious-practices-of-runners-a-1137229.html